Hydrochloric Acid → N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

HRID 745175ノート

反応式

HRID 745175 の反応式
[Cl:1][CH2:2][CH2:3][S:4]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])=[O:5].[CH:14]([NH2:17])([CH3:16])[CH3:15].Cl.CCOCC>CO>[ClH:1].[C:8]1([CH2:7][S:4]([CH2:3][CH2:2][NH:17][CH:14]([CH3:16])[CH3:15])(=[O:6])=[O:5])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 6363IsopropylamineHCID 99230(((2-Chloroethyl)sulfonyl)methyl)benzene

生成物 1

HCID 13655079N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride収率 65.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was partitioned between ether and dilute sodium hydroxide
  3. dry with materialThe ether solution was dried over magnesium sulfate
  4. customthe solvent was removed in vacuo
  5. customto give an oil
  6. customa white solid precipitated

出典と根拠

ORDレコード
ord-4c828b8a9bbe475787be2847289c49cf
出典データセット
uspto-grants-1986_07
特許番号
US04597902

反応ノート

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