Hydrochloric Acid → N'-Phenylcyclobutanecarbohydrazide

HRID 74518ノート

反応式

HRID 74518 の反応式
[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.N1C=CC=CC=1.Cl>CN(C=O)C>[C:8]1([NH:14][NH:15][C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)=[O:6])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 7516PhenylhydrazineHCID 78705Cyclobutanecarbonyl chloride

生成物 1

HCID 13728291N'-Phenylcyclobutanecarbohydrazide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3.54 mL (31.0 mmol) cyclobutanecarboxylic acid chloride were added dropwise at RT to 3.00 mL (30.2 mmol) phenylhydrazine and 4.75 mL (60.0 mmol) pyridine in 30 mL DMF. The mixture was stirred for 1 h at RT and poured onto 200 mL of a 1M hydrochloric acid solution. The precipitated solid was suction filtered, washed with 50 mL water and dried i. vac. The product was extracted with 50 mL ether and suction filtered. The solid was washed with 20 mL ether and dried in the air.

後処理

  1. filtrationfiltered
  2. washwashed with 50 mL water
  3. customdried i
  4. extractionThe product was extracted with 50 mL ether and suction
  5. filtrationfiltered
  6. washThe solid was washed with 20 mL ether
  7. customdried in the air

出典と根拠

ORDレコード
ord-751690bac2704318a4bd743d93e918ee
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

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