Water → HCID 58386508、化合物

HRID 74522

反応式

HRID 74522 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[NH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][CH2:17][C:18]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=O)=[CH:8]1.O>C1COCC1>[N:20]1([CH2:18][CH2:17][CH2:16][C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:7][CH:8]=2)[CH2:24][CH2:23][CH2:22][CH2:21]1

参加物

5

反応物 3

HCID 962WaterHCID 48067833-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-oneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 58386508HCID 58386508、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Under a nitrogen atmosphere 3.40 mL (3.40 mmol) of a 1M lithium aluminium hydride solution in THF was slowly added dropwise to 670 mg (2.77 mmol) 3-(1H-indol-3-yl)-1-pyrrolidin-1-yl-propan-1-one in 30 mL THF. The reaction mixture was stirred for 1 h at 65 C and after cooling combined with 1 mL water. After 10 min stirring at RT the organic phase was dried on sodium sulphate and evaporated down i. vac. The product was reacted further without any further purification.

後処理

  1. temperatureafter cooling
  2. stirringAfter 10 min stirring at RT the organic phase
  3. customwas dried on sodium sulphate
  4. customevaporated down i
  5. customThe product was reacted further without any further purification

出典と根拠

ORDレコード
ord-39f6eb522e4e4be3be7652d682775701
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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