Malonic Acid → 3-Amino-3-(4-methylphenyl)propanoic acid

HRID 745248ノート

反応式

HRID 745248 の反応式
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.[C:10]([OH:16])(=[O:15])[CH2:11]C(O)=O.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:7]([C:4]1[CH:5]=[CH:6][C:1]([CH3:9])=[CH:2][CH:3]=1)[CH2:11][C:10]([OH:16])=[O:15]

参加物

5

反応物 3

HCID 867Malonic AcidHCID 77254-MethylbenzaldehydeHCID 517165Ammonium Acetate

生成物 1

HCID 27336803-Amino-3-(4-methylphenyl)propanoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 10 ml of p-tolualdehyde, were added 180 ml of ethanol, 9.8 g of malonic acid, and 15.8 g of ammonium acetate. The mixture was refluxed for 5 hours. After cooling, the insolubles were removed by filtration. After addition of 100 ml of water, the filtrate was adjusted to pH 7.0 with 1N hydrochloric acid, and the precipitated crystals were collected by filtration to yield 5.4 g of β-amino-β-(4-methylphenyl)propionic acid; m.p. 228°-229° C.

後処理

  1. temperatureThe mixture was refluxed for 5 hours
  2. temperatureAfter cooling
  3. customthe insolubles were removed by filtration
  4. additionAfter addition of 100 ml of water
  5. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-75f73cb4a52a49e8913c11d472063eb0
出典データセット
uspto-grants-1986_07
特許番号
US04598077

反応ノート

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