Hydrochloric Acid → HCID 23315107、化合物

反応式

C(Cl)(Cl)[Cl:2].Cl.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:15]=1[O:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]2[C:29](=[O:30])[C:28]3=[CH:31][CH:32]=[CH:33][CH:34]=[C:27]3[C:26]2=[O:35])=[CH:20][CH:19]=1)[C:11]#[N:12].[CH3:36][OH:37]>>[ClH:2].[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:15]=1[O:16][CH2:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:24][N:25]2[C:29](=[O:30])[C:28]3=[CH:31][CH:32]=[CH:33][CH:34]=[C:27]3[C:26]2=[O:35])=[CH:22][CH:23]=1)[C:11](=[NH:12])[O:37][CH3:36]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 6212Chloroform

HCID 13655344HCID 13655344、化合物

生成物 1

HCID 23315107HCID 23315107、化合物

実験手順

To a mixture of 25 ml of chloroform and 50 ml of anhydrous methanol saturated with anhydrous hydrogen chloride while cooling in ice, was added 4.8 g of 3-methoxy-4-(4 -phthalimidomethylbenzyloxy)benzonitrile. The mixture was stirred at room temperature for 24 hours, then concentrated, and admixed with ethyl acetate to yield 3.4 g of colorless or pink solid methyl 3-methoxy-4-(4-phthalimidomethylbenzyloxy)benzimidate hydrochloride; m.p. 221°-222° C.

後処理

temperaturewhile cooling in ice
concentrationconcentrated

出典と根拠

ORDレコード: ord-915ddc22bcc94d95a70f798fcf9ad9fe
出典データセット: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04598077

反応ノート

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