Benzoyl Peroxide → 3-[2-(Bromomethyl)phenyl]thiophene
反応式
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH3:12])=[CH:2]1.[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:12][Br:13])=[CH:2]1参加物
5
実験手順
To a solution of Compound 2a (7.23 mmol) in carbon tetrachloride (150 mL) was added N-bromosuccinimide (7.5 mmol) and benzoyl peroxide (0.1 g). The solution was heated at reflux and irradiated with 250 watt sunlamp for 2 hours. The cooled reaction mixture was filtered through a pad of silica gel and the silica gel washed with diethyl ether (3×75 mL). The solvent was removed in vacuo and the residue fractionated to afford Compound 2b as a clear oil (b.p. 100°-103° C./0.1 mm).
後処理
- temperatureThe solution was heated
- temperatureat reflux
- customirradiated with 250 watt sunlamp for 2 hours
- customThe cooled reaction mixture
- filtrationwas filtered through a pad of silica gel
- washthe silica gel washed with diethyl ether (3×75 mL)
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-68c5656836c04b0db1ae2c8128d91679
- 出典データセット
- uspto-grants-1986_07
- 特許番号
- US04599341
反応ノート
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