Water → Ethyl 6-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylate

HRID 74559ノート

反応式

HRID 74559 の反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([C:19]2[CH:20]([OH:29])[NH:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:15][CH2:14]1.CCN(C(C)C)C(C)C.O>CN(C=O)C>[O:29]=[C:20]1[C:19]([CH:16]2[CH2:17][CH2:18][N:13]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:3]=3)[CH2:14][CH2:15]2)=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[NH:21]1

参加物

6

反応物 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 22756838Ethyl 6-chloropyrimidine-4-carboxylateHCID 673376243-Piperidin-4-yl-1,2-dihydro-quinolin-2-ol

生成物 1

HCID 58386736Ethyl 6-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

730 mg (3.91 mmol) ethyl 6-chloropyrimidine-4-carboxylate were placed in 10 mL DMF. 900 mg (3.94 mmol) 3-piperidin-4-yl-1,2-dihydro-quinolin-2-ol and 2.30 mL (13.4 mmol) DIPEA were added and the reaction mixture was stirred overnight at RT. The reaction mixture was mixed with 60 mL water and stirred for 30 min. The precipitated solid was suction filtered and dried.

後処理

  1. stirringstirred for 30 min
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-2af5a626b26641d5b8965c6ccdce442c
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

読み込み中…