反応式
[NH:1]1[C:5]2[CH:6]=[C:7]3[CH2:13][O:12][CH2:11][O:10][C:8]3=[CH:9][C:4]=2[N:3]=[C:2]1[SH:14].[OH-].[Na+].[ClH:17].[CH3:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][Cl:26])=[N:23][CH:24]=1>O>[ClH:26].[ClH:17].[CH3:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][S:14][C:2]2[NH:1][C:5]3[CH:6]=[C:7]4[CH2:13][O:12][CH2:11][O:10][C:8]4=[CH:9][C:4]=3[N:3]=2)=[N:23][CH:24]=1参加物
実験手順
To 3.7 g of 1,8-dihydro-m-dioxino(4,5-f)benzimidazole-2-thiol, suspended in 60 ml of alcohol, were added dropwise while stirring 1.5 g of sodium hydroxide in 30 ml of water and, after 30 minutes, there were added 3.4 g of 5-methyl-2-chloromethylpyridine hydrochloride. The mixture was left to boil at reflux overnight, then evaporated and the residue was taken up in methylene chloride. This mixture was washed first with 3N sodium hydroxide, then neutral with water, dried over sodium sulfate and evaporated in vacuo. The crude porduct was dissolved while heating in a small amount of methanol and treated with 25 ml of 5N hydrochloric acid in ethylacetate. There was obtained 1,8-dihydro-2-[[(5-methyl-2-pyridyl)methyl]thio]-m-dioxino(4,5-f)benzimidazole dihydrochloride of melting point 153°-155° C.
後処理
- additionwere added dropwise
- waitThe mixture was left
- temperatureat reflux overnight
- customevaporated
- washThis mixture was washed first with 3N sodium hydroxide
- dry with materialneutral with water, dried over sodium sulfate
- customevaporated in vacuo
- dissolutionThe crude porduct was dissolved
- temperaturewhile heating in a small amount of methanol
- additiontreated with 25 ml of 5N hydrochloric acid in ethylacetate
出典と根拠
- ORDレコード
- ord-e00a739f4fa644628b608610ef8b8b3f
- 出典データセット
- uspto-grants-1986_07
- 特許番号
- US04599347
関連ノート
読み込み中…