Water → (Indolin-3-yl)methanol
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:10](OCC)=[O:11])[CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>C1COCC1>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([CH2:10][OH:11])[CH2:2]1参加物
5
実験手順
0.79 g (3.5 mmol) ethyl 2,3-dihydro-1H-indol-3-carboxylate were added batchwise at RT to 7.8 mL (7.8 mmol) of a 1 M lithium aluminium hydride solution (in THF) in 40 mL THF and refluxed for 1 h. Then the reaction mixture was combined with water while being cooled, the precipitate formed was filtered off and the filtrate was evaporated down.
後処理
- temperaturerefluxed for 1 h
- temperaturewhile being cooled
- customthe precipitate formed
- filtrationwas filtered off
- customthe filtrate was evaporated down
出典と根拠
- ORDレコード
- ord-e16ed823924a41b9a87d54b3aff9207e
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829006B2
反応ノート
読み込み中…