Triethylsilane → methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate

HRID 74572

反応式

HRID 74572 の反応式
C([SiH](CC)CC)C.[N+:8]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[C:13]([C:20](=O)[C:21]([O:23][CH3:24])=[O:22])=[CH:14][NH:15]2)([O-:10])=[O:9]>FC(F)(F)C(O)=O>[N+:8]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH2:14][NH:15]2)([O-:10])=[O:9]

参加物

4

反応物 2

HCID 12052TriethylsilaneHCID 10243717Methyl (4-nitro-1H-indol-3-yl)(oxo)acetate

生成物 1

HCID 10243182methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

Under an argon atmosphere 16 mL (0.10 mmol) triethylsilane were slowly added dropwise to 2.3 g (9.3 mmol) methyl (4-nitro-1H-indol-3-yl)-oxo-acetate in 18 mL trifluoroacetic acid while cooling with ice. Then the mixture was stirred for a further 3 h at RT and evaporated down. The residue was dried and then triturated with diisopropylether, suction filtered and dried in the air.

後処理

  1. temperaturewhile cooling with ice
  2. customevaporated down
  3. customThe residue was dried
  4. customtriturated with diisopropylether, suction
  5. filtrationfiltered
  6. customdried in the air

出典と根拠

ORDレコード
ord-4dc15c7d857a4497b86d2906e813aebc
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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