Ammonia → 4-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine

HRID 745732ノート

反応式

HRID 745732 の反応式
[NH3:1].[CH:2]1([C:5]2[N:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7](C(Cl)(Cl)Cl)[N:6]=2)[CH2:4][CH2:3]1>O1CCCC1>[NH2:1][C:7]1[N:6]=[C:5]([CH:2]2[CH2:4][CH2:3]2)[N:10]=[C:9]([O:11][CH3:12])[N:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 201996182-Cyclopropyl-4-methoxy-6-(trichloromethyl)-1,3,5-triazine

生成物 1

HCID 27265914-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

5 ml of concentrated aqueous ammonia are added to a solution of 1 g of 2-cyclopropyl-4-methoxy-6-trichloromethyl-1,3,5-triazine in 3 ml of tetrahydrofuran; the whole is placed into a bomb tube and heated at 80° C. for 30 minutes. The mixture is cooled and then filtered; the filter residue is dissolved in 30 ml of methylene chloride, and the solution is dried over magnesium sulfate, and concentrated by evaporation. The residue crystallises to leave 0.4 g of white crystals, m.p. 157°-158° C.

後処理

  1. customthe whole is placed into a bomb tube
  2. temperatureThe mixture is cooled
  3. filtrationfiltered
  4. dissolutionthe filter residue is dissolved in 30 ml of methylene chloride
  5. dry with materialthe solution is dried over magnesium sulfate
  6. concentrationconcentrated by evaporation
  7. customThe residue crystallises

出典と根拠

ORDレコード
ord-94f811812539495c9a88c420b11fd8f6
出典データセット
uspto-grants-1986_07
特許番号
US04600428

反応ノート

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