Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 745741ノート

反応式

HRID 745741 の反応式
C(N)CCCCCCCCCCCCCCCC.[CH:19]1([N:25]=[C:26]=[N:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.N(C(OC(C)(C)C)=O)(CC(O)=[O:38])C>C(Cl)(Cl)Cl>[C:26]([NH:25][CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)([NH:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:38]

参加物

5

反応物 3

HCID 10868Dicyclohexylcarbodiimide2 回HCID 15791HeptadecylamineHCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-

生成物 1

HCID 4277N,N'-Dicyclohexylurea

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

C17BocSar1 : the product C17BocSar1 is obtained by coupling heptadecylamine with BocSar1 in the presence of dicyclohexylcarbodiimide (DCCI). 3.78 g (0.02 mole) of BocSar and 2.06 g (0.01 mole) of DCCI are mixed cold (at 0° C.) in 100 ml of chloroform. A copious precipitate of dicyclohexylurea (DCU) is formed. The mixture is left for 30 minutes at 0° C., with agitation, and 2.55 g (0.01 mole) of heptadecylamine are added. The reaction is left to proceed for 20 hours. The precipitate is filtered off and washed, the filtrate is recovered, the chloroform is evaporated off, the residue is taken up in 50 ml of THF, the mixture is cooled to 0° C. and filtered to remove the maximum amount of dicyclohexylurea, and the precipitate is washed with the minimum amount of cold THF.

後処理

  1. customC17BocSar1 : the product C17BocSar1 is obtained

出典と根拠

ORDレコード
ord-65d3e44c71d54ad39804d2efbd1b4efc
出典データセット
uspto-grants-1986_07
特許番号
US04600526

反応ノート

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