Maleic Anhydride → Fluorescein maleamic acid

HRID 745848

反応式

HRID 745848 の反応式
[CH:1]1[C:6]([NH2:7])=[CH:5][C:4]2[C:8]([O:10][C:11]3([C:21]4[CH:22]=[CH:23][C:24]([OH:26])=[CH:25][C:20]=4[O:19][C:13]4[CH:14]=[C:15]([OH:18])[CH:16]=[CH:17][C:12]3=4)[C:3]=2[CH:2]=1)=[O:9].[C:27]1(=[O:33])[O:32][C:30](=[O:31])[CH:29]=[CH:28]1>C(O)(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[C:3]([C:11]2[C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=3[O:19][C:20]3[C:21]=2[CH:22]=[CH:23][C:24]([CH:25]=3)=[O:26])[CH:2]=1.[C:27]([OH:32])(=[O:33])/[CH:28]=[CH:29]\[C:30]([NH2:7])=[O:31]

参加物

4

反応物 2

HCID 7923Maleic AnhydrideHCID 768455-Aminofluorescein

生成物 1

HCID 131714782Fluorescein maleamic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 350 milligrams (0.001 mols) of 5-aminofluorescein and 300 milligrams (excess) of maleic anhydride were mixed in 5.0 milliliters of glacial acetic acid and the mixture was stirred at ambient temperature for 24 hours. The yellow product formed was filtered off and washed three times with diethyl ether. 420 Milligrams of fluorescein-maleamic acid was obtained. 1.R (KBR) showed bands at 2.55; 3.28; 3.38; 4.05; 5.85; 6.30; 6.52; 6.88; 6.90; 7.70; 8.34; 8.52; and 8.30μ.

後処理

  1. customThe yellow product formed
  2. filtrationwas filtered off
  3. washwashed three times with diethyl ether

出典と根拠

ORDレコード
ord-ec89bd94355a4786b06c363daa5e8ec9
出典データセット
uspto-grants-1986_07
特許番号
US04600775

関連ノート

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