Sodium Hydroxide → 2-ethyl-1H-indole

HRID 74589ノート

反応式

HRID 74589 の反応式
C1(S([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH2:19][CH3:20])(=O)=O)C=CC=CC=1.[OH-].[Na+]>CCO>[CH2:19]([C:11]1[NH:10][C:18]2[C:13]([CH:12]=1)=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH3:20]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 100167951H-Indole, 2-ethyl-1-(phenylsulfonyl)-

生成物 1

HCID 38016182-ethyl-1H-indole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.2 g (4.2 mmol) 1-benzenesulphonyl-2-ethyl-1H-indole in 10 mL EtOH were combined with 5 mL of a (20 mmol) 4 N aqueous sodium hydroxide solution and refluxed for 8 h. Then the solvent was eliminated using the rotary evaporator and the residue was diluted with ice water. After acidifying with semi-concentrated aqueous hydrochloric acid the grease precipitated was extracted with ethyl acetate. The organic phase was dried on sodium sulphate, filtered off, evaporated down and dried.

後処理

  1. temperaturerefluxed for 8 h
  2. customthe rotary evaporator
  3. additionthe residue was diluted with ice water
  4. customprecipitated
  5. extractionwas extracted with ethyl acetate
  6. customThe organic phase was dried on sodium sulphate
  7. filtrationfiltered off
  8. customevaporated down
  9. customdried

出典と根拠

ORDレコード
ord-003399a254d34568b19bee9374dea228
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

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