Hydrazine hydrate (1:1) → HCID 13656051、化合物

HRID 745931ノート

反応式

HRID 745931 の反応式
[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11](=O)[CH:10]([CH2:16][C:17]([OH:19])=O)[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:21][NH2:22]>C(O)C>[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11]2=[N:21][NH:22][C:17](=[O:19])[CH2:16][CH:10]2[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 13656050[5-(1H-Imidazol-1-yl)-1-oxo-2,3-dihydro-1H-inden-2-yl]acetic acid

生成物 1

HCID 13656051HCID 13656051、化合物収率 48%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 1.48 g of 2,3-dihydro-5-(1H-imidazol-1-yl)-1-oxo-1H-indene-2-acetic acid and 0.38 g of 85% hydrazine hydrate in 15 ml of ethanol is heated to reflux for three hours. The reaction mixture is filtered, the residue is washed with ethanol and purified by crystallization from ethanol to give 0.7 g of the product, 2,4,4a,5-tetrahydro-7-(1H-imidazol-1-yl)-3H-indeno[1,2-c]pyridazin-3-one, mp 263°-264° dec.

後処理

  1. temperatureto reflux for three hours
  2. filtrationThe reaction mixture is filtered
  3. washthe residue is washed with ethanol
  4. custompurified by crystallization from ethanol

出典と根拠

ORDレコード
ord-e0e5d4a25264406f8fcb0cc7bc50efba
出典データセット
uspto-grants-1986_07
特許番号
US04602019

反応ノート

読み込み中…