3-Bromobenzoic acid → HCID 58386659、化合物

HRID 74605

反応式

HRID 74605 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[F:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH2:16][CH2:15]2.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:5]([N:17]2[C:18]3[C:14](=[CH:13][C:12]([F:11])=[CH:20][CH:19]=3)[CH2:15][CH2:16]2)=[O:7])[CH:8]=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 114563-Bromobenzoic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27744635-Fluoroindoline

生成物 1

HCID 58386659HCID 58386659、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

0.40 g (2.0 mmol) 3-bromobenzoic acid and 0.28 g (2.0 mmol) 5-fluoro-2,3-dihydro-1H-indole in 0.55 mL (4.0 mmol) TEA and 10 mL DCM were combined with 0.64 mg (2.0 mmol) TBTU and stirred overnight at RT. The reaction mixture was extracted with saturated sodium hydrogen carbonate solution and DCM. The combined organic phases were dried on sodium sulphate, filtered and evaporated down. The residue was suspended in MeOH, suction filtered and dried.

後処理

  1. extractionThe reaction mixture was extracted with saturated sodium hydrogen carbonate solution and DCM
  2. customThe combined organic phases were dried on sodium sulphate
  3. filtrationfiltered
  4. customevaporated down
  5. filtrationsuction filtered
  6. customdried

出典と根拠

ORDレコード
ord-aeea0957623645d79d3c0b98b15ffdd9
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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