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3-Bromobenzoic acid → (3-Bromo-phenyl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromobenzoic acid | HCID 11456 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | 5-Fluoroindoline | HCID 2774463 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (3-Bromo-phenyl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58386659 | — |
反応手順
0.40 g (2.0 mmol) 3-bromobenzoic acid and 0.28 g (2.0 mmol) 5-fluoro-2,3-dihydro-1H-indole in 0.55 mL (4.0 mmol) TEA and 10 mL DCM were combined with 0.64 mg (2.0 mmol) TBTU and stirred overnight at RT. The reaction mixture was extracted with saturated sodium hydrogen carbonate solution and DCM. The combined organic phases were dried on sodium sulphate, filtered and evaporated down. The residue was suspended in MeOH, suction filtered and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829006B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-aeea0957623645d79d3c0b98b15ffdd9 |
| 出典メモ | uspto-grants-2014_09 |