Thionyl Chloride → 2-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

HRID 746134ノート

反応式

HRID 746134 の反応式
[Cl:1][C:2]1[S:3][C:4]([C:11]([O:13]CC)=O)=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[S:3][C:4]([C:11]([Cl:18])=[O:13])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 1235240Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate

生成物 1

HCID 132827442-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

実験手順

A mixture of 36.0 g (0.1554 mole) of the acid of Example 17 and 171 g (1.437 mole) of thionyl chloride were held at reflux for 6 hours. Excess thionyl chloride was removed under reduced pressure and the residue (38.1 g, 98%) was reacted as described in Examples 19-31.

後処理

  1. temperatureat reflux for 6 hours
  2. customExcess thionyl chloride was removed under reduced pressure
  3. customthe residue (38.1 g, 98%) was reacted

出典と根拠

ORDレコード
ord-a0f61152d1384babb9cba12f7a5cd96a
出典データセット
uspto-grants-1986_07
特許番号
US04602937

反応ノート

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