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2-Methoxy-2-amino-1-propanol → tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxy-2-amino-1-propanol | HCID 20240818 | — |
| 反応物 | Di-tert-butyl di-carbonate | HCID 52911111 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate | HCID 14578673 | — |
反応手順
2-Methoxy-2-amino-1-propanol is dissolved in saturated aqueous NaHCO3 at room temperature. Di-tert-butyl di-carbonate is added in tert-butanol. The contents are stirred overnight and then extracted with ethyl acetate. The organic layer is dried over MgSO4 and filtered. The filtrate is evaporated to give N-Boc-2-amino-2-methyl-1-propanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04603011 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-1873053f5d6c4ed1bb1425d87b1ec683 |
| 出典メモ | uspto-grants-1986_07 |