Triethylamine → HCID 42613219、化合物

HRID 74629ノート

反応式

HRID 74629 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[O:32]=[C:33]1[N:39]([CH:40]2[CH2:45][CH2:44][N:43]([C:46]3[N:51]=[CH:50][N:49]=[C:48]([C:52](O)=[O:53])[CH:47]=3)[CH2:42][CH2:41]2)[CH2:38][CH2:37][C:36]2[CH:55]=[CH:56][CH:57]=[CH:58][C:35]=2[NH:34]1.C(N(CC)CC)C>CN(C=O)C.CO.O>[N:1]1([C:52]([C:48]2[N:49]=[CH:50][N:51]=[C:46]([N:43]3[CH2:44][CH2:45][CH:40]([N:39]4[CH2:38][CH2:37][C:36]5[CH:55]=[CH:56][CH:57]=[CH:58][C:35]=5[NH:34][C:33]4=[O:32])[CH2:41][CH2:42]3)[CH:47]=2)=[O:53])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

参加物

8

反応物 4

HCID 8471TriethylamineHCID 10328IndolineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 583864046-[4-(2-Oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid

生成物 1

HCID 42613219HCID 42613219、化合物

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

34 μL (0.30 mmol) 2,3-dihydro-1H-indole and 90.0 mg (0.28 mmol) TBTU was added to 100 mg (0.27 mmol) 6-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid and 42 μL (0.30 mmol) triethylamine in 4.0 mL DMF. The mixture was stirred for 1 h at RT and then poured onto 40 mL water. The precipitated product was suction filtered. The solid was stirred with methanol, suction filtered and dried.

後処理

  1. filtrationfiltered
  2. customdried

出典と根拠

ORDレコード
ord-21dd98822cd9439eb62a2c56bbd2475e
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

読み込み中…