Diisopropylethylamine → 1-{1-[6-(5-Chloro-2,3-dihydroindole-1-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

HRID 74633

反応式

HRID 74633 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[N:23]([C:27]([C:29]1[CH:34]=[C:33](Cl)[N:32]=[CH:31][N:30]=1)=[O:28])[CH2:22][CH2:21]2.CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[N:23]([C:27]([C:29]1[N:30]=[CH:31][N:32]=[C:33]([N:1]3[CH2:2][CH2:3][CH:4]([N:7]4[C:15]5[C:10](=[N:11][CH:12]=[CH:13][CH:14]=5)[NH:9][C:8]4=[O:16])[CH2:5][CH2:6]3)[CH:34]=1)=[O:28])[CH2:22][CH2:21]2

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 22293182Bms-973013HCID 58117515(5-Chloro-2,3-dihydroindol-1-yl)-(6-chloropyrimidin-4-yl)-methanone

生成物 1

HCID 583866221-{1-[6-(5-Chloro-2,3-dihydroindole-1-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

80 mg (0.27 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one (dihydrochloride) were added to 100 mg (0.34 mmol) (5-chloro-2,3-dihydroindol-1-yl)-(6-chloropyrimidin-4-yl)-methanone and 100 μL (0.58 mmol) DIPEA in 10 mL DMF. The reaction mixture was stirred for 22 h at RT and then evaporated down i. vac. The residue was combined with 20 mL water and stirred for 30 min at RT. The precipitated product was suction filtered. The purification was carried out using a silica gel column. The product fractions were combined and the solvent was eliminated using the rotary evaporator. The residue was stirred with water, suction filtered and dried.

後処理

  1. customevaporated down i
  2. stirringstirred for 30 min at RT
  3. customThe purification
  4. customthe rotary evaporator
  5. stirringThe residue was stirred with water, suction
  6. filtrationfiltered
  7. customdried

出典と根拠

ORDレコード
ord-3b2d427af17f47889012c9eb56d19d5e
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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