Diisopropylethylamine → HCID 58386576、化合物

HRID 74634ノート

反応式

HRID 74634 の反応式
Cl.Cl.[NH:3]1[CH2:8][CH2:7][CH:6]([N:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[CH2:5][CH2:4]1.[Br:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[N:25]([C:29]([C:31]1[CH:36]=[C:35](Cl)[N:34]=[CH:33][N:32]=1)=[O:30])[CH2:24][CH2:23]2.CCN(C(C)C)C(C)C>CN(C=O)C>[Br:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[N:25]([C:29]([C:31]1[N:32]=[CH:33][N:34]=[C:35]([N:3]3[CH2:4][CH2:5][CH:6]([N:9]4[C:17]5[C:12](=[N:13][CH:14]=[CH:15][CH:16]=5)[NH:11][C:10]4=[O:18])[CH2:7][CH2:8]3)[CH:36]=1)=[O:30])[CH2:24][CH2:23]2

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 222931811-(piperidin-4-yl)-1H,2H,3H-imidazo[4,5-b]pyridin-2-one dihydrochlorideHCID 58386763(5-Bromo-2,3-dihydroindol-1-yl)-(6-chloropyrimidin-4-yl)-methanone

生成物 1

HCID 58386576HCID 58386576、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

70 mg (0.24 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one dihydrochloride were added to 100 mg (0.30 mmol) (5-bromo-2,3-dihydroindol-1-yl)-(6-chloropyrimidin-4-yl)-methanone and 100 μL (0.58 mmol) DIPEA in 10 mL DMF. The reaction mixture was stirred for 22 h at RT and then evaporated down i. vac. The residue was combined with 20 mL water and stirred for 30 min at RT. The precipitated product was suction filtered. The purification was carried out using a silica gel column. The product fractions were combined and the solvent was eliminated using the rotary evaporator. The residue was stirred with water, suction filtered and dried at 40° C. in the CAD.

後処理

  1. customevaporated down i
  2. stirringstirred for 30 min at RT
  3. customThe purification
  4. customthe rotary evaporator
  5. stirringThe residue was stirred with water, suction
  6. filtrationfiltered
  7. customdried at 40° C. in the CAD

出典と根拠

ORDレコード
ord-01abe73218be43969707f51495941028
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

読み込み中…