Hydrochloric Acid → 4-(Trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride
反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH2:9])[N:4]=1.[ClH:12].[H][H]>C(O)(C)C.[Pd]>[ClH:12].[F:11][C:2]([F:1])([F:10])[CH:3]1[NH:4][C:5]([NH2:9])=[N:6][CH2:7][CH2:8]1参加物
6
実験手順
To a solution of 10 g (45.11 mmol) of 4-trifluoromethyl-pyrimidin-2-ylamine and 0.065 g of palladium 10 wt. % on activated carbon in 5 ml of isopropanol was added 45 ml of a solution of hydrochloric acid in isopropanol (5-6 N). The mixture was shaken at 40° C. under hydrogen pressure of 4 atmospheres until hydrogen uptake ceased. The catalyst was removed by filtration and washed with isopropanol. The filtrate was evaporated to dryness to afford 12.14 g of pure product as a white solid.
後処理
- customThe catalyst was removed by filtration
- washwashed with isopropanol
- customThe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-892e1d9c3e594c6d973d0baeef4378f8
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07393853B2
反応ノート
読み込み中…