Potassium Carbonate → Benzooxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine

HRID 746460ノート

反応式

HRID 746460 の反応式
[O:1]1[C:5]2[CH:6]=[C:7]([NH2:10])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[Br:11][C:12]1[N:13]=[C:14](Br)[C:15]2[N:16]([CH:18]=[CH:19][N:20]=2)[CH:17]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[O:1]1[C:5]2[CH:6]=[C:7]([NH:10][C:14]3[C:15]4[N:16]([CH:18]=[CH:19][N:20]=4)[CH:17]=[C:12]([Br:11])[N:13]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5841201,3-Benzoxazol-6-amineHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

生成物 1

HCID 57447606Benzooxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A quantity of 0.13 g (1 mmole) of Benzooxazol-6-ylamine is treated with 0.27 g (1 mmole) of 6,8-Dibromo-imidazo[1,2-a]pyrazine in acetonitrile with 3 eq of K2CO3 at reflux for 16 hrs. The reaction mixture is cooled partitioned between ethyl acetate and water, the organic extracts are dried over anhydrous MgSO4 and evaporated in vacuo to afford benzooxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine.

後処理

  1. temperatureat reflux for 16 hrs
  2. temperatureThe reaction mixture is cooled
  3. custompartitioned between ethyl acetate and water
  4. dry with materialthe organic extracts are dried over anhydrous MgSO4
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-d0cc7d22717641669e8707a51a6d8639
出典データセット
uspto-grants-2008_07
特許番号
US07393848B2

反応ノート

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