Diisopropylethylamine → HCID 58386392、化合物

HRID 74647

反応式

HRID 74647 の反応式
Cl.Cl.[NH:3]1[CH2:8][CH2:7][CH:6]([N:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[CH2:5][CH2:4]1.Cl[C:20]1[N:25]=[CH:24][N:23]=[C:22]([C:26]([N:28]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]([CH3:37])=[CH:29]2)=[O:27])[CH:21]=1.CCN(C(C)C)C(C)C>CN(C=O)C>[CH3:37][C:30]1[C:31]2[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:28]([C:26]([C:22]2[N:23]=[CH:24][N:25]=[C:20]([N:3]3[CH2:4][CH2:5][CH:6]([N:9]4[C:17]5[C:12](=[N:13][CH:14]=[CH:15][CH:16]=5)[NH:11][C:10]4=[O:18])[CH2:7][CH2:8]3)[CH:21]=2)=[O:27])[CH:29]=1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 222931811-(piperidin-4-yl)-1H,2H,3H-imidazo[4,5-b]pyridin-2-one dihydrochlorideHCID 58386489(6-Chloropyrimidin-4-yl)-(3-methylindol-1-yl)-methanone

生成物 1

HCID 58386392HCID 58386392、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

227 mg (0.78 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one dihydrochloride were added to 200 mg (0.74 mmol) (6-chloropyrimidin-4-yl)-(3-methyl-indol-1-yl)-methanone and 413 μL (2.40 mmol) DIPEA in 5 mL DMF. The reaction mixture was stirred overnight at RT and then purified by preparative HPLC. The product fractions were combined and concentrated by rotary evaporation using the rotary evaporator. The residue was taken up in methanol and purified through a silica gel column. The product fractions were combined and concentrated by rotary evaporation using the rotary evaporator.

後処理

  1. custompurified by preparative HPLC
  2. concentrationconcentrated by rotary evaporation
  3. customthe rotary evaporator
  4. custompurified through a silica gel column
  5. concentrationconcentrated by rotary evaporation
  6. customthe rotary evaporator

出典と根拠

ORDレコード
ord-7a1cda7589d945fabbe78371eecc6328
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

読み込み中…