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HRID 746661作成日：2026年10月27日
2,3-Dihydroxybutanedioic Acid → (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate
https://huagongshe.com/reaction/746661
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| 反応物 | Tolterodine | HCID 443879 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate | HCID 9847786 | 71.9% |
反応手順
Tolterodine free base (2.0 gm) is dissolved in methyl tert-butyl ether (25 ml), tartaric acid (1.2 gm) is added and the reaction mass is heated to 40° C. Then the contents are cooled to 25° C., maintained for 2 hours at 25° C. to 30° C. and filtered to give 2.1 gm of tolterodine tartrate form III.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07393874B2 |
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| 出典データセット | uspto-grants-2008_07 |
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| ORD ID | ord-f76e4e4203d24c6e953c60140ebe904d |
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| 出典メモ | uspto-grants-2008_07 |
|---|
