HCID 69148474、化合物 → 4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane

HRID 747020ノート

反応式

HRID 747020 の反応式
[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OCC3C=CC=CC=3)=O)[CH2:8][CH2:7]2)[CH2:5][O:4][C:3]1([CH3:23])[CH3:22]>CO.[Pd]>[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][O:4][C:3]1([CH3:23])[CH3:22]

参加物

4

反応物 1

HCID 69148474HCID 69148474、化合物

生成物 1

HCID 691473354-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Benzyl 4-hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iii) above; 180 mg) was dissolved in methanol and palladium on carbon (5%) was added. The mixture was hydrogenated at atmospheric pressure for 30 min. The catalyst was removed by filtration through Hyflo™ and the solvent was evaporated in vacuo to afford the product as a white solid.

後処理

  1. customThe catalyst was removed by filtration through Hyflo™
  2. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-500f7eb397384da2983159cada5dfeec
出典データセット
uspto-grants-2008_07
特許番号
US07393858B2

反応ノート

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