Trifluoroacetic acid → Trifluoroacetic acid

HRID 747041ノート

反応式

HRID 747041 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:14]=2)[CH2:9]1)(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[N:19]1([CH2:18][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][CH:8]([NH2:7])[CH2:17][CH2:16]3)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 59486432HCID 59486432、化合物

生成物 2

HCID 6422Trifluoroacetic acidHCID 59486397HCID 59486397、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(6-Piperidin-1-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid tert-butyl ester (0.113 g, 0.327 mmol) was suspended in CH2Cl2 (2.5 mL) then TFA was added (2.5 mL). The reaction was stirred at RT until complete consumption of starting material was observed by HPLC analysis (2 h). The reaction mixture was concentrated in vacuo to afford the crude title compound as the bis-TFA salt, which was used without further purification. MS (APCI pos) 245 (M+H).

後処理

  1. customwas observed by HPLC analysis (2 h)
  2. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-ddee342a72bf4f2dbd279623e21e6ef5
出典データセット
uspto-grants-2008_07
特許番号
US07393852B2

反応ノート

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