Chloroacetic Acid → [(2-Propanylideneamino)oxy]acetic acid

HRID 747077ノート

反応式

HRID 747077 の反応式
[CH3:1][C:2](=[N:4][OH:5])[CH3:3].Cl[CH2:7][C:8]([OH:10])=[O:9].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH3:1][C:2](=[N:4][O:5][CH2:7][C:8]([OH:10])=[O:9])[CH3:3]

参加物

6

反応物 3

HCID 300Chloroacetic AcidHCID 14798Sodium HydroxideHCID 67180Acetone, oxime

生成物 1

HCID 79344[(2-Propanylideneamino)oxy]acetic acid

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 1140Toluene溶媒

実験手順

7.3 g of acetone oxime, 14.2 g of chloroacetic acid and 2% of tetrabutylammonium bromide are placed in 80 ml of toluene. An aqueous sodium hydroxide solution (10 g of sodium hydroxide dissolved in 150 ml of water) is added dropwise. The reaction medium is stirred for 1 h and then the toluene is evaporated under vacuum. The residue is then acidified with concentrated hydrochloric acid to pH 2.5, then washed with water and extracted twice with ethyl acetate. The organic phase is dried over sodium sulfate and the solvent is evaporated to give the expected product.

後処理

  1. customthe toluene is evaporated under vacuum
  2. washwashed with water
  3. extractionextracted twice with ethyl acetate
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-20988d9a1e434193b54ddb81c32a440b
出典データセット
uspto-grants-2008_07
特許番号
US07396525B2

反応ノート

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