Guanidine Hydrochloride → 4-(2-Furyl)pyrimidin-2-amine
反応式
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[O:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.[NH2:14][C:15]([NH2:17])=[NH:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[CH:4]=[CH:3][N:14]=[C:15]([NH2:17])[N:16]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
A suspension of 3-(dimethylamino)-1-(2-furyl)-2-propen-1-one (5.0 g, 30.3 mmol), guanidine hydrochloride (5.8 g, 60.7 mmol) and potassium carbonate (8.4 g, 60.9 mmol) in N,N-dimethylformamide (50 ml) was stirred at 100° C. for 21 hours. After cooling as it was, the reaction mixture was diluted with ice water (250 ml). The resulting solid was collected by filtration and washed with water, to give the title compound (4.19 g, 86%) as a pale brown solid.
後処理
- temperatureAfter cooling as it
- filtrationThe resulting solid was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-ba7a7b4ac8394a0d8d1decdb2490eafb
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396836B2
反応ノート
読み込み中…