N-bromobutanimide → 5-Bromo-4-(2-furyl)-2-pyrimidinylamine
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([NH2:12])[N:7]=1.[Br:13]N1C(=O)CCC1=O>CN(C)C=O.C(=O)(O)[O-].[Na+]>[Br:13][C:11]1[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)=[N:7][C:8]([NH2:12])=[N:9][CH:10]=1参加物
5
実験手順
To a solution of 4-(2-furyl)-2-pyrimidinylamine (4.10 g, 25.4 mmol) in N,N-dimethylformamide (40 ml) was added N-bromosuccinimide (4.53 g, 25.5 mmol) at 2° C., followed by stirring as it was. After 6 hours, the reaction mixture was diluted with an aqueous saturated sodium bicarbonate solution (240 ml). The mixture was ice-cooled, and then the crystals were collected by filtration and washed with water, to give the title compound (5.10 g, 84%) as a pale brown solid.
後処理
- temperaturecooled
- filtrationthe crystals were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-868dea27a9774a6195697dd544213120
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396836B2
反応ノート
読み込み中…