Norbornadiene → HCID 59749439、化合物
反応式
[N:1]([CH2:4][CH:5]1[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][CH:11]=2)[CH2:6]1)=[N+:2]=[N-:3].[CH:17]12CC(C=C1)C=[CH:18]2>O1CCOCC1>[Br:16][C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH2:6][CH:5]([CH2:4][N:1]3[CH:18]=[CH:17][N:3]=[N:2]3)[O:9][N:8]=2)=[CH:11][CH:12]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
5-Azidomethyl-3-(4-bromo-phenyl)-4,5-dihydro-isoxazol (12.3 g, 43.6 mmol) and bicyclo[2.2.1]hepta-2,5-diene (23.6 ml, 218.1 mmol) were added to dioxane (200 ml), heated to 100° C. and stirred for six hours. The reaction mixture was concentrated in vacuo followed by addition of ethyl ether (200 ml). The precipitate was collected and washed with ethyl ether (3×20 ml) and dried under nitrogen to give the desired product (8.8 g).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- additionfollowed by addition of ethyl ether (200 ml)
- customThe precipitate was collected
- washwashed with ethyl ether (3×20 ml)
- customdried under nitrogen
出典と根拠
- ORDレコード
- ord-3e50b0ba231a47a58d07fc81d02524df
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396847B2
反応ノート
読み込み中…