(3-Methylpyridin-2-yl)methanol → 3-Methylpyridine-2-carboxaldehyde

HRID 747342

反応式

HRID 747342 の反応式
[OH:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 1514369(3-Methylpyridin-2-yl)methanol

生成物 1

HCID 15018743-Methylpyridine-2-carboxaldehyde収率 64%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

後処理

  1. filtrationthen filtered through celite
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-79276cd25702424f90854d58f89435ed
出典データセット
uspto-grants-2008_07
特許番号
US07396840B2

関連ノート

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