Sodium borohydride → (2-Amino-5-chlorophenyl)(2,5-dichlorophenyl)methanol
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[Cl:18])=[O:10].[BH4-].[Na+]>C(O)C>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]([C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[Cl:18])[OH:10]参加物
4
実験手順
To 6.38 g of (2-amino-5-chlorophenyl)(2,5-dichlorophenyl)methanone dissolved in 50 ml of ethanol are added 2.4 g of sodium borohydride, and the mixture is left for 18 hours at room temperature. The resulting mixture is concentrated and the residue is taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 2.016 g of the expected product.
後処理
- concentrationThe resulting mixture is concentrated
- washwashed with water
- dry with materialThe organic phase is dried over anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d79a53f8faef4b29b48ac87440ffcc58
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396958B2
反応ノート
読み込み中…