Dimethylformamide → 1-(Pyridine-4-yl)-piperidine-4-carboxylate chloride
反応式
Cl.[N:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CN(C)C=O.C(Cl)(=O)C([Cl:25])=O>ClCCl>[Cl-:25].[N:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([O-:16])=[O:15])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1参加物
5
実験手順
7 g (34 mmol) of 1-(pyridine-4-yl)-piperidine-4-carboxylate hydrochloride was stirred in 340 ml of dichloromethane, and 1 ml of dimethylformamide and 10.4 ml (109 mmol) of oxalyl dichloride were added thereto and stirred at room temperature for 1 hour. The solvent was distilled off, and the residue was dried with a vacuum pump to obtain the title compound.
後処理
- distillationThe solvent was distilled off
- customthe residue was dried with a vacuum pump
出典と根拠
- ORDレコード
- ord-2197a7a9cfe3418495ac5a2a708a9c04
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396844B1
反応ノート
読み込み中…