Potassium Hydroxide → 4-(1-Oxo-indan-5-yloxy)-benzamide

HRID 747967

反応式

HRID 747967 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[OH-:20].[K+]>C(O)(C)(C)C>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:19]=[CH:18][C:15]([C:16]([NH2:17])=[O:20])=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 597506434-(1-Oxo-indan-5-yloxy)-benzonitrile

生成物 1

HCID 597506634-(1-Oxo-indan-5-yloxy)-benzamide収率 5.8%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

Combine 4-(1-Oxo-indan-5-yloxy)-benzonitrile (1.64 g, 6.58 mmol), tert-butyl alcohol (50 ml), and grounded KOH (1.85 g, 32.89 mmol) at room temperature under nitrogen atmosphere. Stir the reaction for 24 hours then concentrate under reduced pressure. Add Ethyl acetate to the reaction mixture and wash with brine. Dry the organic layer over Na2SO4. A yellow-orange solid precipitates out to afford 101.0 mg, 0.38 mmol (5.7% yield) of the title compound: No Characterization—Characterized by sequential reaction.

後処理

  1. customat room temperature
  2. customthe reaction for 24 hours
  3. concentrationthen concentrate under reduced pressure
  4. washAdd Ethyl acetate to the reaction mixture and wash with brine
  5. dry with materialDry the organic layer over Na2SO4
  6. customA yellow-orange solid precipitates out

出典と根拠

ORDレコード
ord-4b2cddca66ef48c48ecd3cbdc4be3ebd
出典データセット
uspto-grants-2008_07
特許番号
US07399774B2

関連ノート

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