1H-1,2,4-Triazole → 1-(4-Methoxybenzyl)-1,2,4-triazole

HRID 748061ノート

反応式

HRID 748061 の反応式
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Cl)=[CH:10][CH:9]=1.C1CCN2C(=NCCC2)CC1>C1COCC1>[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 92571H-1,2,4-TriazoleHCID 699934-Methyloxybenzyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

生成物 1

HCID 108453281-(4-Methoxybenzyl)-1,2,4-triazole収率 57%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 1,2,4-triazole (2.0 g, 29 mmol) in THF (80 mL) at 0° C. was added 4-methoxybenzyl chloride (4.0 mL, 29 mmol) and DBU (5.20 mL, 34.7 mmol). The reaction mixture was warmed to room temperature and allowed to stir overnight. The solution was filtered and the filtrate was concentrated. The resulting residue was purified by column chromatography (EtOAc/MeOH, 1:9) to give 3.12 g (57%) of 1-(4-methoxybenzyl)-1H-1,2,4-triazole as a colorless oil.

後処理

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe resulting residue was purified by column chromatography (EtOAc/MeOH, 1:9)

出典と根拠

ORDレコード
ord-ad67110a16d7408c8de6eff2bf355f35
出典データセット
uspto-grants-2008_07
特許番号
US07399778B2

反応ノート

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