Pyridine-2-carbonitrile → HCID 59750340、化合物

HRID 748092ノート

反応式

HRID 748092 の反応式
[CH3:1][O:2][C:3]1[C:4]([SH:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]2[S:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[N:14][C:6](=[O:8])[C:5]=2[CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 7522Pyridine-2-carbonitrileHCID 166556102-Mercapto-3-methoxybenzoic acid

生成物 1

HCID 59750340HCID 59750340、化合物収率 28%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
135 °C

実験手順

A mixture of 3-methoxy-2-mercaptobenzoic acid (1.84 g, 10.0 mmol), 2-cyanopyridine (1.05 g, 10.2 mmol) and pyridine (30.0 ml) was refluxed at 135° C. for 18 hrs as described in Example 9. The mixture was concentrated. The obtained crystals were recrystallized from ethanol to give the titled compound (0.75 g, 28%).

後処理

  1. concentrationThe mixture was concentrated
  2. customThe obtained crystals were recrystallized from ethanol

出典と根拠

ORDレコード
ord-ea5ac8311f524492a103455dfc83fa85
出典データセット
uspto-grants-2008_07
特許番号
US07399759B2

反応ノート

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