6-Methylquinoline → 6-(Bromomethyl)quinoline
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2参加物
5
実験手順
A solution of 6-methylquinoline (5 g, 35 mmol, 1 eq.), N-Bromosuccinimide (8.1 g, 45.5 mmol, 1.3 eq.) and benzoyl peroxide (840 mg, 3.5 mmol, 0.1 eq.) in carbon tetrachloride (100 mL) was stirred at reflux for 3 hours and then cooled to room temperature. The reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in tetrahydrofuran (100 mL) and filtered. The filtrate was directly used in the next step without further purification
後処理
- temperatureat reflux for 3 hours
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated in vacuo
- dissolutionThe residue was dissolved in tetrahydrofuran (100 mL)
- filtrationfiltered
- customThe filtrate was directly used in the next step without further purification
出典と根拠
- ORDレコード
- ord-8c9af432ee0e4b06b9c7fc4fd393edbc
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08828401B2
反応ノート
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