Trifluoroacetic acid → 3-[6-(7-Methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 748239ノート

反応式

HRID 748239 の反応式
[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]2[C:7](=[O:26])[N:8]=[C:9]([C:11]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[CH:4]=1.FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]2[C:7](=[O:26])[N:8]=[C:9]([C:11]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[CH:4]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 22939580tert-Butyl 3-[6-(7-methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate

生成物 1

HCID 597501523-[6-(7-Methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

反応条件

温度
0 °C

実験手順

A mixture of tert-butyl 3-[6-(7-methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.40 g, 1.0 mmol) obtained in Example 173 and trifluoroacetic acid (5.0 ml) was stirred at 0° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure, combined with diisopropyl ether to give the crystals, which were collected by filtration and dried.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto give the crystals, which
  3. filtrationwere collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-ab1b46ece9e947a493bd4a0d9fe126e9
出典データセット
uspto-grants-2008_07
特許番号
US07399759B2

反応ノート

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