tert-Butyl 3-[4-methyl-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate → 3-[4-Methyl-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 748265ノート

反応式

HRID 748265 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[S:9][C:10]3[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[N:13]=2)[N:5]=[C:4]([CH2:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[CH:3]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[S:9][C:10]3[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[N:13]=2)[N:5]=[C:4]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:3]=1

参加物

3

反応物 1

HCID 22939440tert-Butyl 3-[4-methyl-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate

生成物 1

HCID 597501643-[4-Methyl-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid収率 91.9%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
0 °C

実験手順

tert-Butyl 3-[4-methyl-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.44 g, 1.1 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated, and the residue was recrystallized from diisopropyl ether-methanol to give the titled compound (0.33 g, 87%) as white crystals.

後処理

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from diisopropyl ether-methanol

出典と根拠

ORDレコード
ord-962a057889ec49d1802c2f7445590856
出典データセット
uspto-grants-2008_07
特許番号
US07399759B2

反応ノート

読み込み中…