Ethyl Acetate → 6-Chloro-1H-pyrrolo[2,3-b]pyridine
反応式
[Cl:1][C:2]1[N:7]=[C:6]2[N:8](C(C3C=CC=CC=3)=O)[CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[OH-].[Na+].C(OCC)(=O)C>CO>[Cl:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1参加物
5
実験手順
A solution of (Intermediate C3) (3.12 mmol) in MeOH (90 mL) was treated with 1 M NaOH (30 mL) at rt for 18 h. The solution was freed of MeOH under reduced pressure and ethyl acetate was added to the aqueous layer. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with sat. NaHCO3, and dried over Na2SO4. The mixture was filtered and the solvent was evaporated to give a solid 6-chloro-1H-pyrrolo[2,3-b]pyridine (Intermediate C4).
後処理
- additionwas added to the aqueous layer
- extractionThe aqueous layer was extracted with ethyl acetate
- washthe combined organic layers were washed with sat. NaHCO3
- dry with materialdried over Na2SO4
- filtrationThe mixture was filtered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-12104a8f793c40f4a9680a0d47d24369
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07399868B2
反応ノート
読み込み中…