(2-Azido-3-fluoro-propyl)benzene → 1-Fluoro-3-phenylpropan-2-amine

HRID 749299ノート

反応式

HRID 749299 の反応式
[N:1]([CH:4]([CH2:12][F:13])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[N+]=[N-]>CO.[Pd]>[F:13][CH2:12][CH:4]([NH2:1])[CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 1

HCID 22054864(2-Azido-3-fluoro-propyl)benzene

生成物 1

HCID 50645991-Fluoro-3-phenylpropan-2-amine収率 74.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

To a solution of (2-azido-3-fluoro-propyl)benzene (0.6 g) in MeOH (50 mL) was added 10% Pd/C catalyst and the suspension was hydrogenated for 2 hr. at 3 atmospheres pressure. The filtered reaction mixture and MeOH washings were concentrated to an oil which was chromatographed over silica gel with an ammoniated mixture of MeOH/ether (1:9) to give 0.38 g of the title compound. MS ES (M++H)=154.

後処理

  1. concentrationwere concentrated to an oil which
  2. customwas chromatographed over silica gel with an ammoniated mixture of MeOH/ether (1:9)

出典と根拠

ORDレコード
ord-98fe17384f7148449a9ea79d8deada1b
出典データセット
uspto-grants-2008_07
特許番号
US07402604B2

反応ノート

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