Hydrazine hydrate (1:1) → Ethyl 7-chloro-5-methyl-4-oxo-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-carboxylate

HRID 749492ノート

反応式

HRID 749492 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:17](=O)[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:7]([C:12](OCC)=[O:13])[N:8]2[CH3:11])=[CH:4][CH:3]=1.O.[NH2:25][NH2:26]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[N:26][NH:25][C:12](=[O:13])[C:7]=3[N:8]([CH3:11])[C:9]=2[CH:10]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 15461899Ethyl 6-chloro-2-(ethoxycarbonyl)-1-methyl-oxo-1h-indole-3-acetate

生成物 1

HCID 21948013Ethyl 7-chloro-5-methyl-4-oxo-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-carboxylate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 4.38 g (13.5 mmol) of ethyl 6-chloro-2-(ethoxycarbonyl)-1-methyl-α-oxo-1H-indole-3-acetate (disclosed in WO-A-00/44751), of 65 ml of glacial acetic acid and of 2.7 ml (55.7 mmol) of hydrazine monohydrate is brought to reflux for 3 h.

後処理

  1. temperatureto reflux for 3 h.

出典と根拠

ORDレコード
ord-60f996c9746f43e19d78d0c1ae2d190b
出典データセット
uspto-grants-2008_07
特許番号
US07402682B2

反応ノート

読み込み中…