Cesium carbonate → 2-(2,2,3,3,3-Pentafluoropropyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile

HRID 749519

反応式

HRID 749519 の反応式
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][CH:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[Cs+].[Cs+].FC(F)(F)S(O[CH2:30][C:31]([F:37])([F:36])[C:32]([F:35])([F:34])[F:33])(=O)=O>CN(C)C=O>[F:36][C:31]([F:37])([C:32]([F:35])([F:34])[F:33])[CH2:30][C:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][C:2]([F:16])([F:17])[F:1])=[CH:15][CH:14]=1)([C:12]#[N:13])[C:10]#[N:11]

参加物

5

反応物 3

HCID 10796Cesium carbonateHCID 27760192,2,3,3,3-Pentafluoropropyl trifluoromethanesulfonateHCID 22235052(4-(Trifluoromethoxy)benzyl)malononitrile

生成物 1

HCID 222350482-(2,2,3,3,3-Pentafluoropropyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile収率 29%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Using 0.3 g of (4-(trifluoromethoxy)benzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.073 g of cesium carbonate, and 0.35 g of 2,2,3,3,3-pentafluoropropyl trifluoromethanesulfonate, and according to the process described in the Production Example 1, there was obtained 0.12 g of 2-(2,2,3,3,3-pentafluoropropyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile (the present compound (5)).

出典と根拠

ORDレコード
ord-062feb08cf88480ab7deb784467f5087
出典データセット
uspto-grants-2008_07
特許番号
US07402691B2

関連ノート

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