4-(Trifluoromethoxy)benzalmalononitrile → HCID 22235019、化合物

HRID 749602ノート

反応式

HRID 749602 の反応式
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([CH:8]=[C:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1.[CH:18]([Mg]Br)([CH3:20])[CH3:19]>O1CCCC1.[Cu]I>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]([CH:9]([C:12]#[N:13])[C:10]#[N:11])[CH:18]([CH3:20])[CH3:19])=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 8456624-(Trifluoromethoxy)benzalmalononitrileHCID 178418365HCID 178418365、化合物

生成物 1

HCID 22235019HCID 22235019、化合物収率 55%

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Using 1.19 g of (4-(trifluoromethoxy)benzylidene)malononitrile, 20 ml of tetrahydrofuran, a catalytic amount of copper (I) iodide, and a solution of isopropyl magnesium bromide in tetrahydrofuran (prepared from 0.39 g of magnesium, 10 ml of tetrahydrofuran, and 2.36 g of isopropyl bromide), and according to the process described in Reference Production Example 2, there was obtained 0.77 g of (1-(4-(trifluoromethoxy)phenyl)-2-methylpropyl)malononitrile (the intermediate (8)).

出典と根拠

ORDレコード
ord-a6d93204a7514023925d53e0dc302959
出典データセット
uspto-grants-2008_07
特許番号
US07402691B2

反応ノート

読み込み中…