4-(Trifluoromethoxy)benzalmalononitrile → HCID 22235037、化合物

HRID 749603ノート

反応式

HRID 749603 の反応式
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([CH:8]=[C:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1.[CH3:18][Mg]Br>O1CCCC1.[Cu]I>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]([CH:9]([C:12]#[N:13])[C:10]#[N:11])[CH3:18])=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 8456624-(Trifluoromethoxy)benzalmalononitrileHCID 178418573HCID 178418573、化合物

生成物 1

HCID 22235037HCID 22235037、化合物収率 60%

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Using 1.19 g of (4-(trifluoromethoxy)benzylidene)malononitrile 20 ml of tetrahydrofuran, a catalytic amount of copper (I) iodide, and 12.5 ml of a solution of methyl magnesium bromide in tetrahydrofuran (about 1 M, available from Tokyo Kasei Kogyo Co., Ltd), and according to the process described in Reference Production Example 2, there was obtained 0.76 g of (1-(4-(trifluoromethoxy)phenyl)ethyl)malononitrile (the intermediate (10)).

出典と根拠

ORDレコード
ord-66c775e614454c1684ee70fde62bd387
出典データセット
uspto-grants-2008_07
特許番号
US07402691B2

反応ノート

読み込み中…