5-Amino-4-fluoro-2-methylphenol → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline

HRID 7499

反応式

HRID 7499 の反応式
Cl.Cl[C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[N:5][CH:4]=1.[F:17][C:18]1[CH:24]=[C:23]([CH3:25])[C:22]([OH:26])=[CH:21][C:19]=1[NH2:20]>CC(O)CCC>[F:17][C:18]1[CH:24]=[C:23]([CH3:25])[C:22]([OH:26])=[CH:21][C:19]=1[NH:20][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[N:5][CH:4]=1

参加物

4

反応物 2

HCID 101540985-Amino-4-fluoro-2-methylphenolHCID 219910134-Chloro-6,7-dimethoxycinnoline hydrochloride

生成物 1

HCID 219910404-(2-Fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline

試薬・触媒・溶媒 1

HCID 223862-Pentanol溶媒

反応条件

温度
120 °C

実験手順

A solution of 4-chloro-6,7-dimethoxycinnoline hydrochloride (261 mg, 1 mmol), (prepared as described for the starting material in Example 1), and 2-fluoro-5-hydroxy-4-methylaniline (170 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (5 ml) was heated at 120° C. for 3 hours. After cooling, the solid was filtered off, washed with isopropanol and ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline as an hydrochloride salt (301 mg, 82%).

後処理

  1. custom(prepared
  2. temperatureAfter cooling
  3. filtrationthe solid was filtered off
  4. washwashed with isopropanol and ether
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-f2a6c961afe74bd9b766dbe37ed3ddaf
出典データセット
uspto-grants-2006_08
特許番号
US07087602B2

関連ノート

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