Hydrochloric Acid → HCID 67286541、化合物

HRID 75019

反応式

HRID 75019 の反応式
[OH:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl>O=[Pt]=O>[NH2:11][CH:10]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH:2]1[OH:1]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68073-Nitrosalicylic acid

生成物 1

HCID 67286541HCID 67286541、化合物

試薬・触媒・溶媒 1

HCID 345198Adams' catalyst触媒

実験手順

2-Hydroxy-3-nitro-benzoic acid (5.0 g, 27.3 mmol) was mixed with HCl (125 mL of 0.5 M, 62.5 mmol) and dioxoplatinum (1.0 g, 4.4 mmol) in a hydrogenation bottle. The mixture was placed on a Parr shaker (50 psi H2) for 24 hours. The catalyst was filtered and washed with hot H2O. The filtrate was evaporated to provide 3-amino-2-hydroxy-cyclohexanecarboxylic acid as a mixture of stereoisomers which was utilized to the next step without further purification.

後処理

  1. filtrationThe catalyst was filtered
  2. washwashed with hot H2O
  3. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-fe8427b0b8d8469c82886b32f6cd2244
出典データセット
uspto-grants-2014_09
特許番号
US08829007B2

関連ノート

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