Water → 6-chloro-1H-pyrazolo[3,4-d]pyrimidine
反応式
[NH2:1][NH2:2].[Cl:3][C:4]1[N:9]=[C:8](Cl)[C:7]([CH:11]=O)=[CH:6][N:5]=1.O>C1COCC1>[Cl:3][C:4]1[N:9]=[C:8]2[NH:1][N:2]=[CH:11][C:7]2=[CH:6][N:5]=1参加物
5
実験手順
To a stirred solution of hydrazine (Aldrich, 64 mg, 2 mmol) in THF (5 mL), 2,4-Dichloro-pyrimidine-5-carbaldehyde (Example 17, 176 mg, 1 mmol) was added and the mixture was stirred at room temperature for 30 min. The mixture was poured into water and extracted with EtOAc. The extract was dried with sodium sulfate and the solvent was removed to give an orange solid. 128 mg, 82%. MS (M+H)+, 155.
後処理
- extractionextracted with EtOAc
- dry with materialThe extract was dried with sodium sulfate
- customthe solvent was removed
- customto give an orange solid
出典と根拠
- ORDレコード
- ord-d7915d3b22ff4823aa12afe4cc5ad059
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07405220B2
反応ノート
読み込み中…